DNA ligase function

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Structure and function of the DNA ligases encoded by the ... - NCBI2013年9月5日 · Unlike its other nuclear functions, the role of DNA ligase IIIα in alternative NHEJ is independent of its nuclear partner protein, ... tw | twEukaryotic DNA Ligases: Structural and Functional Insights - NCBIThese interactions determine the specific cellular functions of the DNA ligase isozymes. In mammals, defects in DNA ligation have been linked with an ... tw | twDifferential recruitment of DNA Ligase I and III to DNA repair sitesAlthough all three DNA Ligases use the same basic reaction mechanism, they have distinct functions and are not interchangeable ( 3 , 4 ). DNA Ligase I is ...DNA Ligation | NEBIn living organisms, DNA ligases are essential enzymes with critical roles in DNA replication and repair. In the lab, DNA ligation is performed for both cloning ... twStructures of ATP-bound DNA ligase D in a closed domain ...DNA ligases are the sine qua non of genome integrity and essential for DNA replication and repair in all organisms. DNA ligases join 3′-OH and 5′-PO4 ends ...DNA Ligases: Progress and Prospects - Journal of Biological ...DNA ligases are essential guardians of genomic integrity, and ligase ... that most organisms have multiple ligases that either function in DNA replication ...The Inhibitory Effect of Non-Substrate and Substrate DNA on ... - PLOS2016年3月8日 · A >15-fold reduction in T4 DNA ligase self-adenylylation rate when in ... [4] In order to perform their nick-sealing function, DNA ligases ...Full article: DNA ligase III - Taylor & Francis OnlineAbstract · Introduction · Lig3 is Essential for Cellular Viability due to its Role in Mitochondria · Heterologous DNA Ligases can Substitute for Lig3 in ...miR-22 suppresses DNA ligase III addiction in multiple myeloma2018年8月17日 · In this study, we aimed to identify the potential role of DNA ligases as promoters of genomic instability and survival in MM, ...Elevated Expression of DNA Ligase I in Human CancersPurpose: Human DNA ligase I plays an essential role in DNA replication, recombination, and repair by catalyzing the formation of phosphodiester bonds ...


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